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The Collaboration for AIDS Vaccine Discovery

The Collaboration for AIDS Vaccine Discovery (CAVD) is an international network of scientists and experts dedicated to designing a variety of novel HIV vaccine candidates and advancing the most promising candidates to clinical trials.

The CAVD operates on the principle that accelerating progress toward an AIDS vaccine requires the creativity of individual investigators supported by a collaborative approach that emphasizes the sharing of scientific information and the standardization of laboratory techniques and data analysis.

A safe and effective preventative vaccine is the best way to halt the spread of HIV, which newly infects approximately 2.3 million people worldwide each year. Although existing treatment and prevention programs are working, they often don’t reach the poorest and most disenfranchised individuals.

The CAVD was launched by the Bill & Melinda Gates Foundation in July 2006 and now funds a total of 23 three to five year grants with $355 million. In total, the 23 grants support more than 500 investigators across 103 institutions in 20 countries. Three institutions funded through the foundation's Grand Challenges in Global Health (GCGH) program are also collaborating within the framework of the CAVD.

CAVD Goals

To accelerate HIV vaccine research and development by:

  • Conducting collaborative research
  • Designing novel candidate vaccines
  • Improving and standardizing laboratory practices, data analysis, and preserving and sharing materials
  • Introducing promising candidate vaccines to preclinical and clinical trials

Read more about the CAVD

 

Young/Early Career Investigators Recognized

March 2010 Honorees

George Sellhorn, PhD

Seattle Biomedical Research Institute

Dr. Sellhorn was successful in engineering, expressing and purifying stable, soluble heterotrimeric Envelope proteins which are composed of both clade A and clade B protomers. These novel constructs are currently being tested as immunogens in animals.

More about Dr. Sellhorn

Davide Corti, PhD

Institute for Research in Biomedicine

Dr. Corti has made an important contribution to the UCL VDC program on the isolation of novel monoclonal antibodies (MAbs) that neutralise many strains of HIV-1.

More about Dr. Corti

Funded by the:


In support of the:

Progress Report Summaries

Summaries of the annual and interim progress reports from the grants of 20 CAVD consortia are available at the link below. These summaries provide information on the important scientific progress being made by the CAVD researchers.

View Report Summaries

 

Report: 2006-2008 in Review

Read the full report

 

The CAVD Structure

More about the structure